Limb pain DDx

Limb pain – Differential Diagnosis

Common causes

Must Not Miss

Easily missed

Red flags

  • Bilateral leg pain with bowel/bladder dysfunction
  • Cold pulse less leg
  • Hot/painful/swollen joint with little movement
  • Unilateral calf pain, swelling and tenderness
  • Risk factors for DVT
  • Swelling of the entire leg
  • Severe progressive pain
  • Systemic symptoms (fever, weight loss)
  • Immunosuppression

Investigations to consider

  • FBC, CRP/ESR, D-dimers
  • U&Es, LFTs, Blood glucose,
  • Serum uric acid, bone profile, CK, Vitamin D
  • Local X-ray
  • Duplex USS
  • Venography
  • Angiography
  • Nerve conduction studies
  • MRI scan