Muscle pain & weakness DDx

Muscle pain & weakness – Differential Diagnosis

Common causes

Must Not Miss

Easily missed

Red flags

  • Cold pulseless limb
  • Progressive symptoms
  • Systemic symptoms (fever, weight loss)

Investigations to consider

  • FBC, CRP/ESR
  • U&Es, LFTs, TFTs, Bone profile
  • Serum glucose, CK, B12 + Folate
  • Vitamin D
  • Local X-ray
  • EMG
  • Nerve conduction studies
  • Muscle biopsies
  • Lumbar puncture
  • Angiography